Plasma is the liquid portion of human blood. The vast majority of plasma - 92 percent - is composed of water. The other 8 percent of plasma is made up of essential proteins and antibodies that help sustain our body's vital functions. A shortage of any one of these plasma proteins, such as albumin or immunoglobulins, can give rise to one of many life-threatening illnesses.

Albumin is a natural human protein and is manufactured from human plasma. Albumin is used to stabilize blood pressure in shock or sepsis patients who may be albumin-deficient. It is also used to treat burn patients and augment fluid replacement therapy in cardiac surgery and in certain liver disorders.

Indicated for the treatment of primary immunodeficiency disorders associated with defects in humoral immunity. These include but are not limited to congenital X-linked agammaglobulinemia, common variable immunodeficiency, Wiskott-Aldrich syndrome, and severe combined immunodeficiencies. (B)

Sterile solution of tetanus hyperimmune globulin for intramuscular use. HyperTET S/D contains high titers of tetanus antibodies (tetanus antitoxin) and provides passive immunity for those individuals who have low or no immunity to the toxin produced by the tetanus organism, Clostridium tetani. (G)

Sterile solution of high titers of hepatitis B antibodies solution for intramuscular use.

Anti-D Immune Globulin (Human) for intramuscular use is recommended for the prevention of Rh hemolytic disease of the newborn by its administration to the Rh0(D) negative mother within 72 hours after birth of an Rh0(D) positive infant.

Concentrated form of alpha1-antitrypsin (AAT) which raises the levels of AAT in blood and lungs of adults with emphysema due to deficiency of alpha1-proteinase inhibitor (alpha1-antitrypsin deficiency).

Intermediate pastes such as Cryo, Fraction II+III, Fraction V, Anti-Hepatitis B, Anti-D, Anti-Tetanus and others are also available.

We also provide diagnostic products to companies for use in testing kits such as Albumin, Intravenous Immunoglobulins and other products. We also provide reagent grade plasma products to diagnostic companies for testing.

Immune deficiencies are inherited disorders in which one or more components of the human immune system are deficient or not functioning properly. As a result, individuals with immune deficiencies are susceptible to a wide range of infections that can cause serious illness or, in severe cases, death.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a neurological condition which causes progressive nerve damage and weakness in the arms and legs.

Alpha"1"-antitrypsin (AAT) deficiency, also known as Alpha-1, is a genetic (inherited) disorder that causes significant reduction in the naturally-occurring blood protein alpha1-antitrypsin. A low level of alpha1-antitrypsin allows certain enzymes to attack healthy tissues in the body, primarily in the lungs. To replace missing or reduced levels of this protein, physicians often prescribe an alpha1-proteinase inhibitor. Because this therapy augments or replaces AAT, it is known as augmentation therapy.

The human body typically maintains a balance of blood proteins that slow or stop blood flow (in the case of injury) and facilitate blood flow (to prevent blood clots). Blood clotting disorders can disrupt this balance, resulting in blood clots or excessive bleeding (failure to clot).

• Hereditary Antithrombin III (AT III) deficiency is a rare disorder that can increase the risk of blood clots, particularly during surgeries as well as pregnancy and childbirth. A doctor may prescribe ATIII therapy for patients with heredity ATIII deficiency in connection with a surgical procedure, or when they suffer from a thromboembolism.
• Hemophilia is a genetic disorder characterized by the deficiency or absence of one of the blood proteins responsible for clotting. Antihemophilic factor is a concentrate containing factor VIII - one of the clotting factors (blood proteins) - and is used for the treatment of Hemophilia A, a specific type of hemophilia.
• Factor IX concentrate is used in the treatment of Hemophilia B, another specific type of hemophilia. Antihemophilic factor also contains von Willebrand factor - another important factor involved in normal clotting - and is used in the treatment of patients with von Willebrand's disease (VWD) undergoing surgical and/or invasive procedures in whom desmopressin (DDAVP®) is either ineffective or contraindicated. It is not indicated for patients with severe VWD (Type 3) undergoing major surgery.

Several hyperimmune globulin therapies are used to treat patients whose immune systems have been compromised or challenged by exposure to infectious agents. These therapies are concentrated, plasma-derived immunoglobulins, which provide rapid passive immunity immediately following an exposure. These therapies are intended to provide an immediate short-term immune response, and is then supplemented with active immunization to provide long-term immunity. The combination of active and passive immunization optimizes the protection against infectious agents after exposure.

Hyperimmunes are used for a variety of harmful and life-threatening diseases, including tetanus, rabies, hepatitis A& B, congenital rubella, Rh hemolytic disease of the newborn (HDN) and Varicella (chickenpox).

Human albumin may sometimes be administered to restore blood levels and replace damaged blood proteins that occur as a result of severe burns, crushing injuries, surgical procedures or other serious medical events.

Human albumin constitutes about 55% of all plasma proteins. One of albumin's major roles is maintaining colloid osmotic or oncotic pressure, which is essential to keeping fluids in the bloodstream instead of leaking out into other human tissues. Providing albumin by intravenous administration can correct low albumin levels.